[HTML][HTML] Identification of a novel calcium-binding protein that interacts with the integrin αIIb cytoplasmic domain
UP Naik, PM Patel, LV Parise - Journal of Biological Chemistry, 1997 - ASBMB
The mechanism by which platelets regulate the function of integrin α IIb β 3 (or GPIIb/IIIa),
the platelet fibrinogen receptor, is unknown but may involve the binding of proteins or other
factors to integrin cytoplasmic domains. To identify candidate cytoplasmic domain binding
proteins, we screened a human fetal liver cDNA library in the yeast two-hybrid system, using
the α IIb cytoplasmic domain as" bait," and isolated a novel 855-base pair clone. The open
reading frame encodes a novel 191-amino acid polypeptide (termed CIB for calcium-and …
the platelet fibrinogen receptor, is unknown but may involve the binding of proteins or other
factors to integrin cytoplasmic domains. To identify candidate cytoplasmic domain binding
proteins, we screened a human fetal liver cDNA library in the yeast two-hybrid system, using
the α IIb cytoplasmic domain as" bait," and isolated a novel 855-base pair clone. The open
reading frame encodes a novel 191-amino acid polypeptide (termed CIB for calcium-and …