Platelets induce alterations of chemotactic and adhesive properties of endothelial cells mediated through an interleukin-1-dependent mechanism. Implications for …
M Gawaz, K Brand, T Dickfeld, G Pogatsa-Murray… - Atherosclerosis, 2000 - Elsevier
Platelets and alterations of chemotactic and adhesive properties of endothelium play an
important role in the pathophysiology of atherosclerosis. We investigated the effect of
platelets on secretion of monocyte chemotactic protein-1 (MCP-1) and on surface
expression of intercellular adhesion molecule-1 (ICAM-1) of cultured endothelium.
Pretreatment of cultured monolayers of endothelial cells with α-thrombin-activated platelets
significantly enhanced secretion of MCP-1 and ICAM-1 surface expression (P< 0.01) that …
important role in the pathophysiology of atherosclerosis. We investigated the effect of
platelets on secretion of monocyte chemotactic protein-1 (MCP-1) and on surface
expression of intercellular adhesion molecule-1 (ICAM-1) of cultured endothelium.
Pretreatment of cultured monolayers of endothelial cells with α-thrombin-activated platelets
significantly enhanced secretion of MCP-1 and ICAM-1 surface expression (P< 0.01) that …