Using proteomics to identify potential therapeutic targets in platelets.
PB Maguire, M Foy, DJ Fitzgerald - Biochemical Society …, 2005 - europepmc.org
PB Maguire, M Foy, DJ Fitzgerald
Biochemical Society Transactions, 2005•europepmc.orgProteomics has provided powerful new insights into the complex events of the anucleate
platelet and has revealed many potential protein targets in the search for suitable agents for
thrombotic disease. In the present study, we summarize recent proteomic approaches to
analyse specific platelet subproteomes, such as the platelet releasate, the platelet
phosphotyrosine proteome and characterization of the proteins associated with membrane
lipid rafts.
platelet and has revealed many potential protein targets in the search for suitable agents for
thrombotic disease. In the present study, we summarize recent proteomic approaches to
analyse specific platelet subproteomes, such as the platelet releasate, the platelet
phosphotyrosine proteome and characterization of the proteins associated with membrane
lipid rafts.
Proteomics has provided powerful new insights into the complex events of the anucleate platelet and has revealed many potential protein targets in the search for suitable agents for thrombotic disease. In the present study, we summarize recent proteomic approaches to analyse specific platelet subproteomes, such as the platelet releasate, the platelet phosphotyrosine proteome and characterization of the proteins associated with membrane lipid rafts.
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