Regulated changes in the affinity of integrin adhesion receptors (" activation") play an
important role in numerous biological functions including hemostasis, the immune response,
and cell migration. Physiological integrin activation is the result of conformational changes in
the extracellular domain initiated by the binding of cytoplasmic proteins to integrin
cytoplasmic domains. The conformational changes in the extracellular domain are likely
caused by disruption of intersubunit interactions between the α and β transmembrane (TM) …