[HTML][HTML] Determination of the border between the transmembrane and cytoplasmic domains of human integrin subunits
In this study we have determined the position of the C-terminal end of the transmembrane
domains of human integrin subunits (α2, α5, β1, β2) in microsomal membranes using the
glycosylation mapping technique. In contrast to the common view, the transmembrane
helices were found to extend roughly to Phe 1129 in α2, to Phe 1026 in α5, to Ile 757 in β1,
and to His 728 in β2. The α-carbon of the conserved lysine present near the C-terminal end
of the transmembrane helix (Lys 1125 in α2, Lys 1022 in α5, Lys 752 in β1, and Lys 724 in …
domains of human integrin subunits (α2, α5, β1, β2) in microsomal membranes using the
glycosylation mapping technique. In contrast to the common view, the transmembrane
helices were found to extend roughly to Phe 1129 in α2, to Phe 1026 in α5, to Ile 757 in β1,
and to His 728 in β2. The α-carbon of the conserved lysine present near the C-terminal end
of the transmembrane helix (Lys 1125 in α2, Lys 1022 in α5, Lys 752 in β1, and Lys 724 in …