Summary MYH9‐related disease (MYH9‐RD) is an autosomal dominant disorder deriving
from mutations in the MYH9 gene encoding for the heavy chain of non‐muscle myosin IIA,
and characterized by thrombocytopenia and giant platelets. Isoform IIA of myosin is the only
one expressed in platelets, but the possibility that MYH9 mutations affect the organization of
contractile structures in these blood elements has never been investigated. In this work we
have analyzed the composition and the agonist‐induced reorganization of the platelet …