[HTML][HTML] A truncated isoform of c-Mpl with an essential C-terminal peptide targets the full-length receptor for degradation
J Coers, C Ranft, RC Skoda - Journal of Biological Chemistry, 2004 - ASBMB
Thrombopoietin and its cognate receptor c-Mpl are the primary regulators of
megakaryopoiesis and platelet production. They also play an important role in the
maintenance of hematopoietic stem cells. Here, we have analyzed the function of a
truncated Mpl receptor isoform (Mpl-tr), which results from alternative splicing. The mpl-tr
variant is the only alternate mpl isoform conserved between mouse and humans, suggesting
a relevant function in regulating Mpl signaling. Despite the presence of a signal peptide and …
megakaryopoiesis and platelet production. They also play an important role in the
maintenance of hematopoietic stem cells. Here, we have analyzed the function of a
truncated Mpl receptor isoform (Mpl-tr), which results from alternative splicing. The mpl-tr
variant is the only alternate mpl isoform conserved between mouse and humans, suggesting
a relevant function in regulating Mpl signaling. Despite the presence of a signal peptide and …