Expression of membrane-bound and soluble receptor activator of NF-κB ligand (RANKL) in human T cells

F Kanamaru, H Iwai, T Ikeda, A Nakajima, I Ishikawa… - Immunology letters, 2004 - Elsevier
The receptor activator of NF-κB ligand (RANKL) and its receptor RANK are critical regulators
for immune responses as well as bone remodeling. RANKL is a type II transmembrane
protein that has two forms—a membrane-anchored protein and a secreted protein. In this
report, we demonstrate for the first time the kinetical expression of two forms of RANKL in
human T cells using two monoclonal antibodies (mAbs) against human RANKL, which we
newly derived. Freshly isolated T cells rarely expressed mRANKL, while the activation of T …