[HTML][HTML] The voltage-dependent calcium channel β subunit contains two stable interacting domains
Y Opatowsky, O Chomsky-Hecht, MG Kang… - Journal of Biological …, 2003 - ASBMB
Voltage-dependent calcium channels selectively enable Ca 2+ ion movement through
cellular membranes. These multiprotein complexes are involved in a wide spectrum of
biological processes such as signal transduction and cellular homeostasis. α 1 is the
membrane pore-forming subunit, whereas β is an intracellular subunit that binds to α 1,
facilitating and modulating channel function. We have expressed, purified, and
characterized recombinant β 3 and β 2a using both biochemical and biophysical methods …
cellular membranes. These multiprotein complexes are involved in a wide spectrum of
biological processes such as signal transduction and cellular homeostasis. α 1 is the
membrane pore-forming subunit, whereas β is an intracellular subunit that binds to α 1,
facilitating and modulating channel function. We have expressed, purified, and
characterized recombinant β 3 and β 2a using both biochemical and biophysical methods …