Calcium sparks in human ventricular cardiomyocytes from patients with terminal heart failure
M Lindner, MC Brandt, H Sauer, J Hescheler, T Böhle… - Cell Calcium, 2002 - Elsevier
Cardiomyocytes from terminally failing hearts display significant abnormalities in e–c-
coupling, contractility and intracellular Ca2+ handling. This study is the first to demonstrate
the influence of end-stage heart failure on specific properties of Ca2+ sparks in human
ventricular cardiomyocytes. We investigated the frequency and characteristics of
spontaneously arising Ca2+ sparks in single isolated human myocytes from terminally
failing (HF) and non-failing (NF) control myocardium by using the Ca2+ indicator Fluo-3. The …
coupling, contractility and intracellular Ca2+ handling. This study is the first to demonstrate
the influence of end-stage heart failure on specific properties of Ca2+ sparks in human
ventricular cardiomyocytes. We investigated the frequency and characteristics of
spontaneously arising Ca2+ sparks in single isolated human myocytes from terminally
failing (HF) and non-failing (NF) control myocardium by using the Ca2+ indicator Fluo-3. The …