Deposition of Alzheimer's β-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans
S Vogelgesang, I Cascorbi, E Schroeder… - Pharmacogenetics …, 2002 - journals.lww.com
Deposition of the β-amyloid peptide (Aβ) in the brain occurs during normal ageing and is
substantially accelerated in patients with Alzheimer's disease. Since Aβ is continuously
produced in the brain, it has been suggested that a clearance mechanism should exist to
prevent its accumulation and subsequent aggregation. Until now, little attention has been
paid to the possible role of P-glycoprotein (P-gp), a member of the ATP binding cassette
superfamily of transporter proteins, in the pathogenesis of Alzheimer's disease. A recent …
substantially accelerated in patients with Alzheimer's disease. Since Aβ is continuously
produced in the brain, it has been suggested that a clearance mechanism should exist to
prevent its accumulation and subsequent aggregation. Until now, little attention has been
paid to the possible role of P-glycoprotein (P-gp), a member of the ATP binding cassette
superfamily of transporter proteins, in the pathogenesis of Alzheimer's disease. A recent …