Early plasmacytoid dendritic cell changes predict plasma HIV load rebound during primary infection
J Pacanowski, L Develioglu, I Kamga… - The Journal of …, 2004 - academic.oup.com
J Pacanowski, L Develioglu, I Kamga, M Sinet, M Desvarieux, PM Girard, A Hosmalin
The Journal of infectious diseases, 2004•academic.oup.comDuring human immunodeficiency virus (HIV) infection, interruption of highly active
antiretroviral therapy (HAART) is usually followed by virus load rebound. Previous data have
suggested a role for plasmacytoid dendritic cells (pDCs) in anti-HIV innate immunity. Here,
the number of pDCs was measured by flow cytometry before, during, and after receipt of
HAART in 7 patients with documented primary HIV-1 infection. A negative correlation was
evidenced between pDC counts after 1 month of HAART and mean plasma virus load after …
antiretroviral therapy (HAART) is usually followed by virus load rebound. Previous data have
suggested a role for plasmacytoid dendritic cells (pDCs) in anti-HIV innate immunity. Here,
the number of pDCs was measured by flow cytometry before, during, and after receipt of
HAART in 7 patients with documented primary HIV-1 infection. A negative correlation was
evidenced between pDC counts after 1 month of HAART and mean plasma virus load after …
Abstract
During human immunodeficiency virus (HIV) infection, interruption of highly active antiretroviral therapy (HAART) is usually followed by virus load rebound. Previous data have suggested a role for plasmacytoid dendritic cells (pDCs) in anti-HIV innate immunity. Here, the number of pDCs was measured by flow cytometry before, during, and after receipt of HAART in 7 patients with documented primary HIV-1 infection. A negative correlation was evidenced between pDC counts after 1 month of HAART and mean plasma virus load after interruption of HAART (r2 = 0.85; Spearman's partial ρ = −0.92; P = .03). pDC counts during treatment might help predict immune replication control after interruption of HAART.
Oxford University Press