[HTML][HTML] DC-SIGN and L-SIGN are high affinity binding receptors for hepatitis C virus glycoprotein E2
PY Lozach, H Lortat-Jacob, ADL De Lavalette… - Journal of Biological …, 2003 - ASBMB
The hepatitis C virus (HCV) genome codes for highly mannosylated envelope proteins,
which are naturally retained in the endoplasmic reticulum. We found that the HCV envelope
glycoprotein E2 binds the dendritic cell-specific intercellular adhesion molecule 3-grabbing
nonintegrin (DC-SIGN) and the related liver endothelial cell lectin L-SIGN through high-
mannose N-glycans. Competing ligands such as mannan and an antibody directed against
the carbohydrate recognition domains (CRD) abrogated binding. While no E2 interaction …
which are naturally retained in the endoplasmic reticulum. We found that the HCV envelope
glycoprotein E2 binds the dendritic cell-specific intercellular adhesion molecule 3-grabbing
nonintegrin (DC-SIGN) and the related liver endothelial cell lectin L-SIGN through high-
mannose N-glycans. Competing ligands such as mannan and an antibody directed against
the carbohydrate recognition domains (CRD) abrogated binding. While no E2 interaction …