[HTML][HTML] A novel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR: subunit organization and binding to multivalent ligands
DA Mitchell, AJ Fadden, K Drickamer - Journal of Biological Chemistry, 2001 - ASBMB
DC-SIGN and DC-SIGNR are cell-surface receptors that mediate cell-cell interactions within
the immune system by binding to intercellular adhesion molecule-3. The receptor
polypeptides share 77% amino acid sequence identity and are type II transmembrane
proteins. The extracellular domain of each comprises seven 23-residue tandem repeats and
a C-terminal C-type carbohydrate-recognition domain (CRD). Cross-linking, equilibrium
ultracentrifugation, and circular dichroism studies of soluble recombinant fragments of DC …
the immune system by binding to intercellular adhesion molecule-3. The receptor
polypeptides share 77% amino acid sequence identity and are type II transmembrane
proteins. The extracellular domain of each comprises seven 23-residue tandem repeats and
a C-terminal C-type carbohydrate-recognition domain (CRD). Cross-linking, equilibrium
ultracentrifugation, and circular dichroism studies of soluble recombinant fragments of DC …