Desmoglein as a target in autoimmunity and infection
M Amagai - Journal of the American Academy of Dermatology, 2003 - Elsevier
Clinical phenotypes of most diseases are complex. However, once the mechanism behind
the scene is clarified, the nature shows amazing beauty. There is a simple logic behind a
complex disease. The exact molecular mechanism of the blister formation in staphylococcal
scalded skin syndrome (SSSS) remained to be elucidated for 3 decades since exfoliative
toxin was discovered by Melish and Glasgow in 1970. A knowledge accumulated to
understand the pathogenesis of pemphigus and cell-cell adhesion of keratinocytes led us to …
the scene is clarified, the nature shows amazing beauty. There is a simple logic behind a
complex disease. The exact molecular mechanism of the blister formation in staphylococcal
scalded skin syndrome (SSSS) remained to be elucidated for 3 decades since exfoliative
toxin was discovered by Melish and Glasgow in 1970. A knowledge accumulated to
understand the pathogenesis of pemphigus and cell-cell adhesion of keratinocytes led us to …