Apoptosis Induced by Staphylococcus aureus in Epithelial Cells Utilizes a Mechanism Involving Caspases 8 and 3
CA Wesson, J Deringer, LE Liou, KW Bayles… - Infection and …, 2000 - Am Soc Microbiol
CA Wesson, J Deringer, LE Liou, KW Bayles, GA Bohach, WR Trumble
Infection and immunity, 2000•Am Soc MicrobiolIn this study, we demonstrate that the mechanism by which Staphylococcus aureus induces
apoptosis in bovine mammary epithelial (MAC-T) cells involves caspases 8 and 3, two key
components of a proteolytic cascade leading to apoptosis. In addition, internalized S. aureus
induces expression of the inflammatory cytokines tumor necrosis factor alpha and interleukin-
1β by MAC-T cells. These data suggest that the internalization of S. aureus could induce
specific cellular responses in vivo that may ultimately impact the course of infection.
apoptosis in bovine mammary epithelial (MAC-T) cells involves caspases 8 and 3, two key
components of a proteolytic cascade leading to apoptosis. In addition, internalized S. aureus
induces expression of the inflammatory cytokines tumor necrosis factor alpha and interleukin-
1β by MAC-T cells. These data suggest that the internalization of S. aureus could induce
specific cellular responses in vivo that may ultimately impact the course of infection.
Abstract
In this study, we demonstrate that the mechanism by whichStaphylococcus aureus induces apoptosis in bovine mammary epithelial (MAC-T) cells involves caspases 8 and 3, two key components of a proteolytic cascade leading to apoptosis. In addition, internalized S. aureus induces expression of the inflammatory cytokines tumor necrosis factor alpha and interleukin-1β by MAC-T cells. These data suggest that the internalization of S. aureus could induce specific cellular responses in vivo that may ultimately impact the course of infection.
American Society for Microbiology