In the dentate gyrus of the hippocampus, cell birth and maturation into neurons, or
neurogenesis, occur throughout the lifetime of animals and humans. Multiple factors have
been shown to regulate adult neurogenesis, and a number of findings in this field have had
a large impact on basic and clinical research in depression. It has been reported that both
physical and psychosocial stress paradigms, as well as some animal models of depression,
produce a decrease in hippocampal cell proliferation and neurogenesis. Conversely, long …