Acute experimental pancreatitis and NF-κB/Rel activation
H Algül, Y Tando, G Schneider, H Weidenbach, G Adler… - Pancreatology, 2002 - Elsevier
Acute pancreatitis is a serious disease with a high morbidity and an overall mortality rate of
about 10%. However, in its most severe form, which is characterized by pancreatic necrosis,
20–30% of the patients die. Death is often the result of multiorgan dysfunction, including
acute respiratory, kidney, and hepatic failure as well as generalized diffuse capillary leak
water retention, hypoxia, and acid/base disturbance. The mechanisms by which distant
organ systems are involved still remain obscure, but several lines of evidence suggest the …
about 10%. However, in its most severe form, which is characterized by pancreatic necrosis,
20–30% of the patients die. Death is often the result of multiorgan dysfunction, including
acute respiratory, kidney, and hepatic failure as well as generalized diffuse capillary leak
water retention, hypoxia, and acid/base disturbance. The mechanisms by which distant
organ systems are involved still remain obscure, but several lines of evidence suggest the …