[HTML][HTML] Dynamic Interaction between the Dual Specificity Phosphatase MKP7 and theJNK3 Scaffold Protein β-Arrestin2
EA Willoughby, MK Collins - Journal of Biological Chemistry, 2005 - ASBMB
JNK scaffold proteins bind JNK and upstream kinases to activate subsets ofJNK and localize
activated JNK to specific subcellular sites. We previouslydemonstrated that the dual
specificity phosphatases (DSPs) MKP7 and M3/6 bindthe scaffold JNK-interacting protein-1
(JIP-1) and inactivate the bound subsetof JNK (1). The Gprotein-coupled receptor (GPCR)
adaptor β-arrestin 2 is also a JNK3scaffold. It binds the upstream kinases ASK1 and MKK4
and couples stimulationof the angiotensin II receptor AT1aR to activation of a cytoplasmic …
activated JNK to specific subcellular sites. We previouslydemonstrated that the dual
specificity phosphatases (DSPs) MKP7 and M3/6 bindthe scaffold JNK-interacting protein-1
(JIP-1) and inactivate the bound subsetof JNK (1). The Gprotein-coupled receptor (GPCR)
adaptor β-arrestin 2 is also a JNK3scaffold. It binds the upstream kinases ASK1 and MKK4
and couples stimulationof the angiotensin II receptor AT1aR to activation of a cytoplasmic …