[HTML][HTML] The origin of FOXP3-expressing CD4+ regulatory T cells: thymus or periphery
S Sakaguchi - The Journal of clinical investigation, 2003 - Am Soc Clin Investig
The Journal of clinical investigation, 2003•Am Soc Clin Investig
Naturally arising CD4+ regulatory T cells, which engage in the maintenance of immunologic
self-tolerance, specifically express FOXP3, which encodes a transcription-repressor protein.
Genetic defects in FOXP3 cause IPEX, an X-linked autoimmune/inflammatory syndrome.
With FOXP3 as a specific marker for regulatory CD4+ T cells in humans, it is now possible to
determine their origin and developmental pathway.
self-tolerance, specifically express FOXP3, which encodes a transcription-repressor protein.
Genetic defects in FOXP3 cause IPEX, an X-linked autoimmune/inflammatory syndrome.
With FOXP3 as a specific marker for regulatory CD4+ T cells in humans, it is now possible to
determine their origin and developmental pathway.
Naturally arising CD4+ regulatory T cells, which engage in the maintenance of immunologic self-tolerance, specifically express FOXP3, which encodes a transcription-repressor protein. Genetic defects in FOXP3 cause IPEX, an X-linked autoimmune/inflammatory syndrome. With FOXP3 as a specific marker for regulatory CD4+ T cells in humans, it is now possible to determine their origin and developmental pathway .
The Journal of Clinical Investigation