[HTML][HTML] γ1-and γ2-syntrophins, two novel dystrophin-binding proteins localized in neuronal cells
G Piluso, M Mirabella, E Ricci, A Belsito… - Journal of Biological …, 2000 - ASBMB
Dystrophin is the scaffold of a protein complex, disrupted in inherited muscular dystrophies.
At the last 3′ terminus of the gene, a protein domain is encoded, where syntrophins are
tightly bound. These are a family of cytoplasmic peripheral membrane proteins. Three genes
have been described encoding one acidic (α1) and two basic (β1 and β2) proteins of∼ 57–
60 kDa. Here, we describe the characterization of two novel putative members of the
syntrophin family, named γ1-and γ2-syntrophins. The human γ1-syntrophin gene is …
At the last 3′ terminus of the gene, a protein domain is encoded, where syntrophins are
tightly bound. These are a family of cytoplasmic peripheral membrane proteins. Three genes
have been described encoding one acidic (α1) and two basic (β1 and β2) proteins of∼ 57–
60 kDa. Here, we describe the characterization of two novel putative members of the
syntrophin family, named γ1-and γ2-syntrophins. The human γ1-syntrophin gene is …