[HTML][HTML] Akt Is a Direct Target of the Phosphatidylinositol 3-Kinase: ACTIVATION BY GROWTH FACTORS, v-src and v-Ha-ras, IN Sf9 AND MAMMALIAN CELLS
K Datta, A Bellacosa, TO Chan, PN Tsichlis - Journal of Biological …, 1996 - ASBMB
The Akt protooncogene encodes a serine-threonine protein kinase which is activated by
growth factor-generated signals that are transduced via the phosphatidylinositol 3′-kinase
(PI3-K). Earlier studies suggested that the activation of Akt by PI3-K may be mediated by the
binding of D 3-phosphorylated phosphoinositides to the Akt pleckstrin homology (PH)
domain. On the basis of these studies, it was hypothesized that Akt is a direct PI3-K target.
To test this hypothesis, we reconstituted the pathway of Akt activation in baculovirus-infected …
growth factor-generated signals that are transduced via the phosphatidylinositol 3′-kinase
(PI3-K). Earlier studies suggested that the activation of Akt by PI3-K may be mediated by the
binding of D 3-phosphorylated phosphoinositides to the Akt pleckstrin homology (PH)
domain. On the basis of these studies, it was hypothesized that Akt is a direct PI3-K target.
To test this hypothesis, we reconstituted the pathway of Akt activation in baculovirus-infected …