[HTML][HTML] Ras induction of superoxide activates ERK-dependent angiogenic transcription factor HIF-1α and VEGF-A expression in shock wave-stimulated osteoblasts
FS Wang, CJ Wang, YJ Chen, PR Chang… - Journal of Biological …, 2004 - ASBMB
Vascular endothelial growth factor (VEGF) released by osteoblasts plays an important role in
angiogenesis and endochondral ossification during bone formation. In animal studies, we
have reported that shock waves (SW) can promote osteogenic differentiation of
mesenchymal stem cells through superoxide-mediated signal transduction (Wang, FS,
Wang, CJ, Sheen-Chen, SM, Kuo, YR, Chen, RF, and Yang, KD (2002) J. Biol. Chem. 277,
10931–10937) and vascularization of the bone-tendon junction. Here, we found that SW …
angiogenesis and endochondral ossification during bone formation. In animal studies, we
have reported that shock waves (SW) can promote osteogenic differentiation of
mesenchymal stem cells through superoxide-mediated signal transduction (Wang, FS,
Wang, CJ, Sheen-Chen, SM, Kuo, YR, Chen, RF, and Yang, KD (2002) J. Biol. Chem. 277,
10931–10937) and vascularization of the bone-tendon junction. Here, we found that SW …