Ischemic stroke triggers lipid peroxidation and neuronal injury. Docosahexaenoic acid
released from membrane phospholipids during brain ischemia is a major source of lipid
peroxides. Leukocyte infiltration and pro-inflammatory gene expression also contribute to
stroke damage. In this study using lipidomic analysis, we have identified stereospecific
messengers from docosahexaenoate-oxygenation pathways in a mouse stroke model.
Aspirin, widely used to prevent cerebrovascular disease, activates an additional pathway …