[HTML][HTML] Tumor necrosis factor-α, interleukin-1β, and interferon-γ stimulate γ-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent …
YF Liao, BJ Wang, HT Cheng, LH Kuo… - Journal of Biological …, 2004 - ASBMB
The deposition of the amyloid β (Aβ) peptide in neuritic plaques plays a critical role in the
pathogenesis of Alzheimer's disease (AD). Aβ is generated through the proteolysis of
amyloid precursor protein (APP) by the sequential actions of β-and γ-secretases. Although
recent evidence has unveiled much about the biochemical identity and characteristics of γ-
secretase, the mechanism regulating endogenous γ-secretase activity remains elusive. To
identify possible extracellular signals and associated signaling cascades that could regulate …
pathogenesis of Alzheimer's disease (AD). Aβ is generated through the proteolysis of
amyloid precursor protein (APP) by the sequential actions of β-and γ-secretases. Although
recent evidence has unveiled much about the biochemical identity and characteristics of γ-
secretase, the mechanism regulating endogenous γ-secretase activity remains elusive. To
identify possible extracellular signals and associated signaling cascades that could regulate …