Induction of dependence on ethanol by free-choice drinking in alcohol-preferring rats
MB Waller, WJ McBride, L Lumeng, TK Li - … Biochemistry and Behavior, 1982 - Elsevier
Studies were performed to examine whether chronic, voluntary consumption of ethanol by
the selectively-bred, alcohol-preferring P-rats produces physical dependence. Body weight
reduction, food restriction and flavoring the 10% ethanol solution increased ethanol
consumption from 7 to 14 g ethanol/kg body weight/day when water was freely available.
Under similar conditions, consumption by selectively-bred, alcohol-nonpreferring NP-rats
increased from 1 to 12 g/kg/day. Removal of ethanol after eight weeks induced physical …
the selectively-bred, alcohol-preferring P-rats produces physical dependence. Body weight
reduction, food restriction and flavoring the 10% ethanol solution increased ethanol
consumption from 7 to 14 g ethanol/kg body weight/day when water was freely available.
Under similar conditions, consumption by selectively-bred, alcohol-nonpreferring NP-rats
increased from 1 to 12 g/kg/day. Removal of ethanol after eight weeks induced physical …