Cellular remodeling during progression of dilation involves focal adhesion contact
reorganization. However, the signaling mechanisms and structural consequences leading to
impaired cardiomyocyte adhesion are poorly defined. These events were studied in
tropomodulin-overexpressing transgenic mice that develop dilated cardiomyopathy
associated with chronic elevation of intracellular calcium. Analysis of tropomodulin-
overexpressing transgenic hearts by immunoblot and confocal microscopy revealed …