[HTML][HTML] Anti-apoptotic effect of cGMP in cultured astrocytes: inhibition by cGMP-dependent protein kinase of mitochondrial permeable transition pore
K Takuma, P Phuagphong, E Lee, K Mori… - Journal of Biological …, 2001 - ASBMB
Reperfusion of cultured astrocytes with normal medium after exposure to H 2 O 2-containing
medium causes apoptosis. We have recently shown that ibudilast, which has been used for
bronchial asthma and cerebrovascular disorders, attenuated the H 2 O 2-induced apoptosis
of astrocytes via the cGMP signaling pathway. This study examines the mechanism
underlying the protective effect of cGMP. The membrane-permeable cGMP analog dibutyryl-
cGMP attenuated the H 2 O 2-induced decrease in cell viability, DNA ladder formation …
medium causes apoptosis. We have recently shown that ibudilast, which has been used for
bronchial asthma and cerebrovascular disorders, attenuated the H 2 O 2-induced apoptosis
of astrocytes via the cGMP signaling pathway. This study examines the mechanism
underlying the protective effect of cGMP. The membrane-permeable cGMP analog dibutyryl-
cGMP attenuated the H 2 O 2-induced decrease in cell viability, DNA ladder formation …