Hepatic cytoprotection by nitric oxide and the cGMP pathway after ischaemia–reperfusion in the rat
CH Cottart, V Nivet-Antoine, L Do, G Al-Massarani… - Nitric Oxide, 2003 - Elsevier
Many studies in diverse models suggest that nitric oxide (NO) may be protective against liver
injury due to ischaemia–reperfusion (IR). We evaluated, in an experimental in vivo model of
rat liver partial ischaemia, the effects of pretreatment by an NO donor (spermineNONOate,
5mg/kg), and exogenous cGMP (8Br-cGMP, 16mg/kg) or an endogenous cGMP producer
(ANP, 10μg/kg), to assess their beneficial effects. After 6h of reperfusion, 8Br-cGMP
completely prevented the adverse effect of Nω-nitro-l-arginine (10mg/kg) and 8Br-cGMP …
injury due to ischaemia–reperfusion (IR). We evaluated, in an experimental in vivo model of
rat liver partial ischaemia, the effects of pretreatment by an NO donor (spermineNONOate,
5mg/kg), and exogenous cGMP (8Br-cGMP, 16mg/kg) or an endogenous cGMP producer
(ANP, 10μg/kg), to assess their beneficial effects. After 6h of reperfusion, 8Br-cGMP
completely prevented the adverse effect of Nω-nitro-l-arginine (10mg/kg) and 8Br-cGMP …