Targeting mTOR signaling for cancer therapy

S Huang, PJ Houghton - Current opinion in pharmacology, 2003 - Elsevier
The mammalian target of rapamycin (mTOR), an atypical serine/threonine kinase, plays a
central role in the regulation of cell proliferation, growth, differentiation, migration and
survival. Dysregulation of mTOR signaling occurs in diverse human tumours, and can confer
higher susceptibility to inhibitors of mTOR. Rapamycin and its derivatives, CCI-779 and
RAD001 (designated rapamycins), specifically inhibit the function of mTOR, leading to
inactivation of ribosomal S6K1 and inhibition of cap-dependent translation initiation through …