[HTML][HTML] Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1
F Scarlatti, C Bauvy, A Ventruti, G Sala… - Journal of Biological …, 2004 - ASBMB
The sphingolipid ceramide is involved in the cellular stress response. Here we demonstrate
that ceramide controls macroautophagy, a major lysosomal catabolic pathway. Exogenous
C 2-ceramide stimulates macroautophagy (proteolysis and accumulation of autophagic
vacuoles) in the human colon cancer HT-29 cells by increasing the endogenous pool of long
chain ceramides as demonstrated by the use of the ceramide synthase inhibitor fumonisin B
1. Ceramide reverted the interleukin 13-dependent inhibition of macroautophagy by …
that ceramide controls macroautophagy, a major lysosomal catabolic pathway. Exogenous
C 2-ceramide stimulates macroautophagy (proteolysis and accumulation of autophagic
vacuoles) in the human colon cancer HT-29 cells by increasing the endogenous pool of long
chain ceramides as demonstrated by the use of the ceramide synthase inhibitor fumonisin B
1. Ceramide reverted the interleukin 13-dependent inhibition of macroautophagy by …