[HTML][HTML] Macroautophagy is required for multicellular development of the social amoeba Dictyostelium discoideum

GP Otto, MY Wu, N Kazgan, OR Anderson… - Journal of Biological …, 2003 - ASBMB
Macroautophagy is a mechanism employed by eukaryotic cells to recycle non-essential
cellular components during starvation, differentiation, and development. Two conjugation
reactions related to ubiquitination are essential for autophagy: Apg12p conjugation to
Apg5p, and Apg8p conjugation to the lipid phosphatidylethanolamine. These reactions
require the action of the E1-like enzyme, Apg7p, and the E2-like enzymes, Apg3p and
Apg10p. InDictyostelium, development is induced by starvation, conditions under which …