[HTML][HTML] The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein
Smac/Diablo and HtrA2/Omi are inhibitors of apoptosis (IAP)-binding proteins released from
the mitochondria of human cells during apoptosis and regulate apoptosis by liberating
caspases from IAP inhibition. Here we describe the identification of a proteolytically
processed isoform of the polypeptide chain-releasing factor GSPT1/eRF3 protein, which
functions in translation, as a new IAP-binding protein. In common with other IAP-binding
proteins, the processed GSPT1 protein harbors a conserved N-terminal IAP-binding motif …
the mitochondria of human cells during apoptosis and regulate apoptosis by liberating
caspases from IAP inhibition. Here we describe the identification of a proteolytically
processed isoform of the polypeptide chain-releasing factor GSPT1/eRF3 protein, which
functions in translation, as a new IAP-binding protein. In common with other IAP-binding
proteins, the processed GSPT1 protein harbors a conserved N-terminal IAP-binding motif …