[HTML][HTML] Sequence requirements for Hid binding and apoptosis regulation in the baculovirus inhibitor of apoptosis Op-IAP: Hid binds Op-IAP in a manner similar to …
It has been suggested that theDrosophila Hid protein interacts with the baculovirus Op-IAP
protein in a manner similar to that of human Smac binding to XIAP, based largely on amino
acid sequence homology. However, there is little direct experimental evidence in support of
this hypothesis; indeed, evidence exists from previous studies suggesting that the mode of
binding is not similar. We have now precisely mapped the interaction between Hid and Op-
IAP, and we show clearly for the first time that the biochemical interactions between the …
protein in a manner similar to that of human Smac binding to XIAP, based largely on amino
acid sequence homology. However, there is little direct experimental evidence in support of
this hypothesis; indeed, evidence exists from previous studies suggesting that the mode of
binding is not similar. We have now precisely mapped the interaction between Hid and Op-
IAP, and we show clearly for the first time that the biochemical interactions between the …