[HTML][HTML] X-linked inhibitor of apoptosis protein functions as a cofactor in transforming growth factor-β signaling
SB Reffey, JU Wurthner, WT Parks, AB Roberts… - Journal of Biological …, 2001 - ASBMB
X-linked inhibitor of apoptosis protein (XIAP) is a potent suppressor of apoptotic cell death,
which functions by directly inhibiting caspases, the principal effectors of apoptosis. Here we
report that XIAP can also function as a cofactor in the regulation of gene expression by
transforming growth factor-β (TGF-β). XIAP, but not the related proteins c-IAP1 or c-IAP2,
associated with several members of the type I class of the TGF-β receptor superfamily and
potentiated TGF-β-induced signaling. Although XIAP-mediated activation of c-Jun N-terminal …
which functions by directly inhibiting caspases, the principal effectors of apoptosis. Here we
report that XIAP can also function as a cofactor in the regulation of gene expression by
transforming growth factor-β (TGF-β). XIAP, but not the related proteins c-IAP1 or c-IAP2,
associated with several members of the type I class of the TGF-β receptor superfamily and
potentiated TGF-β-induced signaling. Although XIAP-mediated activation of c-Jun N-terminal …