[HTML][HTML] Caspases: pharmacological manipulation of cell death
IN Lavrik, A Golks, PH Krammer - The Journal of clinical …, 2005 - Am Soc Clin Investig
IN Lavrik, A Golks, PH Krammer
The Journal of clinical investigation, 2005•Am Soc Clin InvestigCaspases, a family of cysteine proteases, play a central role in apoptosis. During the last
decade, major progress has been made to further understand caspase structure and
function, providing a unique basis for drug design. This Review gives an overview of
caspases and their classification, structure, and substrate specificity. We also describe the
current knowledge of how interference with caspase signaling can be used to
pharmacologically manipulate cell death.
decade, major progress has been made to further understand caspase structure and
function, providing a unique basis for drug design. This Review gives an overview of
caspases and their classification, structure, and substrate specificity. We also describe the
current knowledge of how interference with caspase signaling can be used to
pharmacologically manipulate cell death.
Caspases, a family of cysteine proteases, play a central role in apoptosis. During the last decade, major progress has been made to further understand caspase structure and function, providing a unique basis for drug design. This Review gives an overview of caspases and their classification, structure, and substrate specificity. We also describe the current knowledge of how interference with caspase signaling can be used to pharmacologically manipulate cell death.
The Journal of Clinical Investigation