[HTML][HTML] Differential modulation of apoptosis sensitivity in CD95 type I and type II cells
C Scaffidi, I Schmitz, J Zha, SJ Korsmeyer… - Journal of Biological …, 1999 - ASBMB
We have recently identified two different pathways of CD95-mediated apoptosis (Scaffidi, C.,
Fulda, S., Srinivasan, A., Feng, L., Friesen, C., Tomaselli, KJ, Debatin, K.-M., Krammer, PH,
and Peter, ME (1998) EMBO J. 17, 1675–1687). CD95-mediated apoptosis in type I cells is
initiated by large amounts of active caspase-8 formed at the death-inducing signaling
complex (DISC) followed by direct cleavage of caspase-3. In contrast, in type II cells very
little DISC and small amounts of active caspase-8 sufficient to induce the apoptogenic …
Fulda, S., Srinivasan, A., Feng, L., Friesen, C., Tomaselli, KJ, Debatin, K.-M., Krammer, PH,
and Peter, ME (1998) EMBO J. 17, 1675–1687). CD95-mediated apoptosis in type I cells is
initiated by large amounts of active caspase-8 formed at the death-inducing signaling
complex (DISC) followed by direct cleavage of caspase-3. In contrast, in type II cells very
little DISC and small amounts of active caspase-8 sufficient to induce the apoptogenic …