[HTML][HTML] Crystal structure of caspase-2, apical initiator of the intrinsic apoptotic pathway

A Schweizer, C Briand, MG Grutter - Journal of Biological Chemistry, 2003 - ASBMB
The cell death protease caspase-2 has recently been recognized as the most apical
caspase in the apoptotic cascade ignited during cell stress signaling. Cytotoxic stress, such
as that caused by cancer therapies, leads to activation of caspase-2, which acts as a direct
effector of the mitochondrion-dependent apoptotic pathway resulting in programmed cell
death. Here we report the x-ray structure of caspase-2 in complex with the inhibitor acetyl-
Leu-Asp-Glu-Ser-Asp-aldehyde at 1.65-Å resolution. Compared with other caspases …