[HTML][HTML] Caspase-dependent activation of calpain during drug-induced apoptosis
DE Wood, EW Newcomb - Journal of Biological Chemistry, 1999 - ASBMB
We have previously demonstrated that calpain is responsible for the cleavage of Bax, a
proapoptotic protein, during drug-induced apoptosis of HL-60 cells (Wood, DE, Thomas, A.,
Devi, LA, Berman, Y., Beavis, RC, Reed, JC, and Newcomb, EW (1998) Oncogene 17, 1069–
1078). Here we show the sequential activation of caspases and calpain during drug-induced
apoptosis of HL-60 cells. Time course experiments using the topoisomerase I inhibitor 9-
amino-20 (S)-camptothecin revealed that cleavage of caspase-3 substrates poly (ADP …
proapoptotic protein, during drug-induced apoptosis of HL-60 cells (Wood, DE, Thomas, A.,
Devi, LA, Berman, Y., Beavis, RC, Reed, JC, and Newcomb, EW (1998) Oncogene 17, 1069–
1078). Here we show the sequential activation of caspases and calpain during drug-induced
apoptosis of HL-60 cells. Time course experiments using the topoisomerase I inhibitor 9-
amino-20 (S)-camptothecin revealed that cleavage of caspase-3 substrates poly (ADP …