The Bcl2 family: regulators of the cellular life-or-death switch
S Cory, JM Adams - Nature Reviews Cancer, 2002 - nature.com
S Cory, JM Adams
Nature Reviews Cancer, 2002•nature.comTissue homeostasis is regulated by apoptosis, the cell-suicide programme that is executed
by proteases called caspases. The Bcl2 family of intracellular proteins is the central
regulator of caspase activation, and its opposing factions of anti-and pro-apoptotic members
arbitrate the life-or-death decision. Apoptosis is often impaired in cancer and can limit
conventional therapy. A better understanding of how the Bcl2 family controls caspase
activation should result in new, more effective therapeutic approaches.
by proteases called caspases. The Bcl2 family of intracellular proteins is the central
regulator of caspase activation, and its opposing factions of anti-and pro-apoptotic members
arbitrate the life-or-death decision. Apoptosis is often impaired in cancer and can limit
conventional therapy. A better understanding of how the Bcl2 family controls caspase
activation should result in new, more effective therapeutic approaches.
Abstract
Tissue homeostasis is regulated by apoptosis, the cell-suicide programme that is executed by proteases called caspases. The Bcl2 family of intracellular proteins is the central regulator of caspase activation, and its opposing factions of anti- and pro-apoptotic members arbitrate the life-or-death decision. Apoptosis is often impaired in cancer and can limit conventional therapy. A better understanding of how the Bcl2 family controls caspase activation should result in new, more effective therapeutic approaches.
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