[HTML][HTML] Extracellular signal-regulated kinases 1/2 are serum-stimulated “BimEL kinases” that bind to the BH3-only protein BimEL causing its phosphorylation and …
R Ley, KE Ewings, K Hadfield, E Howes… - Journal of Biological …, 2004 - ASBMB
Bim, a" BH3-only" protein, is expressed de novo following withdrawal of serum survival
factors and promotes cell death. We have shown previously that activation of the ERK1/2
pathway promotes phosphorylation of Bim EL, targeting it for degradation via the
proteasome. However, the nature of the kinase responsible for Bim EL phosphorylation
remained unclear. We now show that Bim EL is phosphorylated on at least three sites in
response to activation of the ERK1/2 pathway. By using the peptidylprolyl isomerase, Pin1 …
factors and promotes cell death. We have shown previously that activation of the ERK1/2
pathway promotes phosphorylation of Bim EL, targeting it for degradation via the
proteasome. However, the nature of the kinase responsible for Bim EL phosphorylation
remained unclear. We now show that Bim EL is phosphorylated on at least three sites in
response to activation of the ERK1/2 pathway. By using the peptidylprolyl isomerase, Pin1 …