Mitochondrial and plasma membrane potentials cause unusual accumulation and retention of rhodamine 123 by human breast adenocarcinoma-derived MCF-7 cells.
S Davis, MJ Weiss, JR Wong, TJ Lampidis… - Journal of Biological …, 1985 - ASBMB
Quantitative studies of MCF-7 cells (derived from human breast adenocarcinoma) and CV-1
cells (from normal African green monkey kidney epithelium), using the permeant cationic
compound tetraphenylphosphonium (TPP), in conjunction with fluorescence microscopy
using rhodamine 123 (Rh123), indicate that the mitochondrial and plasma membrane
potentials affect both uptake and retention of these compounds. Under conditions that
depolarize the plasma membrane, uptake and retention of TPP and Rh123, driven only by …
cells (from normal African green monkey kidney epithelium), using the permeant cationic
compound tetraphenylphosphonium (TPP), in conjunction with fluorescence microscopy
using rhodamine 123 (Rh123), indicate that the mitochondrial and plasma membrane
potentials affect both uptake and retention of these compounds. Under conditions that
depolarize the plasma membrane, uptake and retention of TPP and Rh123, driven only by …