[HTML][HTML] Interaction with a membrane surface triggers a reversible conformational change in Bax normally associated with induction of apoptosis
The Bcl-2 family member Bax is an apoptosis-promoting protein that normally resides in an
inactive state within the cytoplasm of healthy cells. Upon induction of apoptosis by diverse
stimuli, Bax undergoes a conformational change and translocates to mitochondria, where it
oligomerizes and forms pores that allow the release of cytochrome c and other cytotoxic
factors. Protein-protein interactions between Bax and other Bcl-2 family members are
strongly implicated in Bax activation, but a compelling case has recently been made for the …
inactive state within the cytoplasm of healthy cells. Upon induction of apoptosis by diverse
stimuli, Bax undergoes a conformational change and translocates to mitochondria, where it
oligomerizes and forms pores that allow the release of cytochrome c and other cytotoxic
factors. Protein-protein interactions between Bax and other Bcl-2 family members are
strongly implicated in Bax activation, but a compelling case has recently been made for the …