Four deaths and a funeral: from caspases to alternative mechanisms
M Leist, M Jäättelä - Nature reviews Molecular cell biology, 2001 - nature.com
Nature reviews Molecular cell biology, 2001•nature.com
A single family of proteases, the caspases, has long been considered the pivotal
executioner of all programmed cell death. However, recent findings of evolutionarily
conserved, caspase-independent controlled death mechanisms have opened new
perspectives on the biology of cell demise, with particular implications for neurobiology,
cancer research and immunological processes.
executioner of all programmed cell death. However, recent findings of evolutionarily
conserved, caspase-independent controlled death mechanisms have opened new
perspectives on the biology of cell demise, with particular implications for neurobiology,
cancer research and immunological processes.
Abstract
A single family of proteases, the caspases, has long been considered the pivotal executioner of all programmed cell death. However, recent findings of evolutionarily conserved, caspase-independent controlled death mechanisms have opened new perspectives on the biology of cell demise, with particular implications for neurobiology, cancer research and immunological processes.
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