[HTML][HTML] Systematic evaluation of anti-apoptotic growth factor signaling in vascular smooth muscle cells: only phosphatidylinositol 3′-kinase is important
M Vantler, E Caglayan, WH Zimmermann… - Journal of Biological …, 2005 - ASBMB
Peptide growth factors contribute to the pathogenesis of cardiovascular diseases by
inducing a variety of cellular responses including anti-apoptotic effects. Several of the
signaling molecules that are activated by growth factor receptors such as Src family kinases
(Src), phosphatidylinositol 3′-kinase (PI3K), phospholipase Cγ (PLCγ), Ras, and SHP-2
were shown to mediate survival signals. We systematically investigated the relative
contribution of each signaling molecule for growth factor-dependent cell survival in vascular …
inducing a variety of cellular responses including anti-apoptotic effects. Several of the
signaling molecules that are activated by growth factor receptors such as Src family kinases
(Src), phosphatidylinositol 3′-kinase (PI3K), phospholipase Cγ (PLCγ), Ras, and SHP-2
were shown to mediate survival signals. We systematically investigated the relative
contribution of each signaling molecule for growth factor-dependent cell survival in vascular …