[HTML][HTML] Pharmacological manipulation of Bcl-2 family members to control cell death
A Letai - The Journal of clinical investigation, 2005 - Am Soc Clin Investig
The Journal of clinical investigation, 2005•Am Soc Clin Investig
The commitment to programmed cell death involves complex interactions among pro-and
antiapoptotic members of the Bcl-2 family of proteins. The physiological result of a decision
by these proteins to undergo cell death is permeabilization of the mitochondrial outer
membrane. Pharmacologic manipulation of proteins in this family appears both feasible and
efficacious, whether the goal is decreased cell death, as in ischemia of the myocardium or
brain, or increased cell death, as in cancer.
antiapoptotic members of the Bcl-2 family of proteins. The physiological result of a decision
by these proteins to undergo cell death is permeabilization of the mitochondrial outer
membrane. Pharmacologic manipulation of proteins in this family appears both feasible and
efficacious, whether the goal is decreased cell death, as in ischemia of the myocardium or
brain, or increased cell death, as in cancer.
The commitment to programmed cell death involves complex interactions among pro- and antiapoptotic members of the Bcl-2 family of proteins. The physiological result of a decision by these proteins to undergo cell death is permeabilization of the mitochondrial outer membrane. Pharmacologic manipulation of proteins in this family appears both feasible and efficacious, whether the goal is decreased cell death, as in ischemia of the myocardium or brain, or increased cell death, as in cancer.
The Journal of Clinical Investigation