[HTML][HTML] Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs
CM Adams, J Reitz, JK De Brabander… - Journal of Biological …, 2004 - ASBMB
The current paper demonstrates that cholesterol and its hydroxylated derivative, 25-
hydroxycholesterol (25-HC), inhibit cholesterol synthesis by two different mechanisms, both
involving the proteins that control sterol regulatory element-binding proteins (SREBPs),
membrane-bound transcription factors that activate genes encoding enzymes of lipid
synthesis. Using methyl-β-cyclodextrin as a delivery vehicle, we show that cholesterol enters
cultured Chinese hamster ovary cells and elicits a conformational change in SREBP …
hydroxycholesterol (25-HC), inhibit cholesterol synthesis by two different mechanisms, both
involving the proteins that control sterol regulatory element-binding proteins (SREBPs),
membrane-bound transcription factors that activate genes encoding enzymes of lipid
synthesis. Using methyl-β-cyclodextrin as a delivery vehicle, we show that cholesterol enters
cultured Chinese hamster ovary cells and elicits a conformational change in SREBP …