Impaired brain development and hydrocephalus in a line of transgenic mice with liver-specific expression of human insulin-like growth factor binding protein-1
S Doublier, C Duyckaerts, D Seurin… - Growth Hormone & IGF …, 2000 - Elsevier
Insulin-like growth factors (IGFs) produced in the brain are known to participate in brain
development via activation of the type 1 IGF receptor. IGF binding proteins (IGFBPs)
modulate the cellular action of IGFs and some are expressed in the fetal brain. Under normal
conditions IGFBP-1 is not one of these, but IGFBP-1 expression obtained via transgenesis
using ubiquitous promoters affects brain development. In earlier work, we established a
model of transgenic mouse in which liver-specific IGFBP-1 expression begins during fetal …
development via activation of the type 1 IGF receptor. IGF binding proteins (IGFBPs)
modulate the cellular action of IGFs and some are expressed in the fetal brain. Under normal
conditions IGFBP-1 is not one of these, but IGFBP-1 expression obtained via transgenesis
using ubiquitous promoters affects brain development. In earlier work, we established a
model of transgenic mouse in which liver-specific IGFBP-1 expression begins during fetal …