[HTML][HTML] SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-α in the adipose tissue of obese mice
B Emanuelli, P Peraldi, C Filloux, C Chavey… - Journal of Biological …, 2001 - ASBMB
SOCS (suppressor of cytokine signaling) proteins are inhibitors of cytokine signaling
involved in negative feedback loops. We have recently shown that insulin increases SOCS-3
mRNA expression in 3T3-L1 adipocytes. When expressed, SOCS-3 binds to phosphorylated
Tyr 960 of the insulin receptor and prevents Stat 5B activation by insulin. Here we show that
in COS-7 cells SOCS-3 decreases insulin-induced insulin receptor substrate 1 (IRS-1)
tyrosine phosphorylation and its association with p85, a regulatory subunit of …
involved in negative feedback loops. We have recently shown that insulin increases SOCS-3
mRNA expression in 3T3-L1 adipocytes. When expressed, SOCS-3 binds to phosphorylated
Tyr 960 of the insulin receptor and prevents Stat 5B activation by insulin. Here we show that
in COS-7 cells SOCS-3 decreases insulin-induced insulin receptor substrate 1 (IRS-1)
tyrosine phosphorylation and its association with p85, a regulatory subunit of …