[HTML][HTML] Molecular mechanisms of insulin receptor substrate protein-mediated modulation of insulin signalling
AM Johnston, L Pirola, E Van Obberghen - FEBS letters, 2003 - Elsevier
AM Johnston, L Pirola, E Van Obberghen
FEBS letters, 2003•ElsevierThe insulin receptor substrate (IRS) proteins act as important mediators of insulin action.
Their regulation serves to augment the specificity of the insulin signalling cascade. They can
be regulated–both positively and negatively–at the level of phosphorylation, and signalling
through these proteins can be further modulated through the actions of SOCS (suppressor of
cytokine signalling) proteins. Understanding the mechanisms of IRS regulation will provide
further insight into the pathophysiology of insulin resistance and type 2 diabetes.
Their regulation serves to augment the specificity of the insulin signalling cascade. They can
be regulated–both positively and negatively–at the level of phosphorylation, and signalling
through these proteins can be further modulated through the actions of SOCS (suppressor of
cytokine signalling) proteins. Understanding the mechanisms of IRS regulation will provide
further insight into the pathophysiology of insulin resistance and type 2 diabetes.
The insulin receptor substrate (IRS) proteins act as important mediators of insulin action. Their regulation serves to augment the specificity of the insulin signalling cascade. They can be regulated – both positively and negatively – at the level of phosphorylation, and signalling through these proteins can be further modulated through the actions of SOCS (suppressor of cytokine signalling) proteins. Understanding the mechanisms of IRS regulation will provide further insight into the pathophysiology of insulin resistance and type 2 diabetes.
Elsevier